09 November 2018, London, UK – Intract Pharma Ltd has successfully been awarded funding from Innovate UK, the UK’s innovation agency, to develop a scalable manufacturing process for novel oral antibody products using its proprietary Soteria® technology. The collaborative industrial research project, totalling over £1.4 million, was secured through the Industrial Strategy Challenge Fund for innovative projects in medicines manufacturing. This program will be conducted by a consortium led by Intract, including the Centre for Process Innovation (CPI), Pharmidex and Quay Pharma.

Each member of the consortium brings unique expertise in drug development and manufacture, with an extensive understanding of pharmaceutical formulation. The project seeks to develop a manufacturing process for Intract’s revolutionary Soteria® technology which can be scaled in a commercially viable manner. Soteria® transforms painful and inconvenient injectable therapies into safe, simple oral formulations, and allows targeting and concentration of the antibody at the site of disease in the gut to improve therapeutic efficacy whilst minimising risk of systemic toxicity.

Intract’s CEO, Bill Lindsay, highlighted that the funding will provide a significant boost to both internal and external development programmes using the technology. “Intract has invested significant resource in developing Soteria® at laboratory scale – Innovate UK funding is critical at this point to resolve the issues involved in large-scale GMP manufacture of biologic drugs.”

Dr Graeme Cruickshank, CPI Director of Formulation, said: “We are delighted to be supporting Intract’s work on developing a manufacturing process for antibody products, which has great potential to improve patients’ treatment. Our position within the consortium also allows us to demonstrate the breadth of capabilities we have here at CPI and how we have been able to bring them to bear to offer our support.”

Dr Christopher Ireson, Pharmidex Head of Oncology, said: “Pharmidex is delighted to be part of this opportunity to support the development of orally delivered therapeutics to the patient.”

Dr. Alison Foster, Technical Manager at Quay Pharmaceuticals, said “Quay is very pleased to be part of this exciting opportunity using Intract’s proprietary technology together with Quay’s expertise to ensure that the formulation developed at CPI and the process is scalable and commercially viable.”

About Intract Pharma

Intract Pharma is an oral drug delivery specialist, developing state-of-the-art formulation technologies and unique gastrointestinal models to develop advanced new therapeutics. Since its inception, Intract has pursued innovation in oral drug delivery as a means to improve on current therapies, making them safer and more effective for patients. Soteria® is available for license exclusively from Intract Pharma. For more information visit www.intractpharma.com

About CPI

The Centre for Process Innovation is a UK-based technology innovation centre and part of the High Value Manufacturing Catapult. The company uses applied knowledge in science and engineering combined with state-of-the-art development facilities to enable its clients to develop, prove, prototype and scale up the next generation of products and processes. Its open innovation model enables clients to develop products and prove processes with minimal risk. CPI provides assets and expertise, so customers can demonstrate processes before investing substantial amounts of money in capital equipment and training. New products and processes can be shown to be feasible; on paper, in the lab and in the plant before being manufactured at an industrial scale. By utilising its proven assets and expertise, companies can take their products and processes to market faster. There is no down time in production as all of the process development is completed offsite and CPI’s technology transfer and engineering teams can help companies transfer the product or process into full-scale production at speed.

About Pharmidex

Pharmidex provides translational solutions using its world-renowned expertise in CNS/Oncology, drug discovery and ADMET/PK.  Founded in the UK in 2002, Pharmidex operates in state-of-the-art facilities in London and Hatfield to provide high quality bespoke experimental data to support drug discovery & development.

About Quay Pharma

Quay Pharmaceuticals is experienced in providing a comprehensive out-sourcing service for formulation and analytical development with subsequent clinical trials manufacturing for pharmaceutical and biotechnology companies worldwide. Working as a dedicated, pro-active part of your team we apply strong project management and technical expertise to take products quickly and cost effectively from late stage pre-clinical through to the end of phase II clinical trials. Quay Pharmaceuticals has built a reputation for specialising in the formulation of APIs that exhibit poor solubility and bio-availability and those which require modified or controlled release.

About Innovate UK

Innovate UK drives productivity and economic growth by supporting businesses to develop and realise the potential of new ideas. We connect businesses to the partners, customers and investors that can help them turn ideas into commercially successful products and services and business growth. We fund business and research collaborations to accelerate innovation and drive business investment into R&D. Our support is available to businesses across all economic sectors, value chains and UK regions. Innovate UK is part of UK Research and Innovation. For more information visit www.innovateuk.ukri.org



London, 23rd November 2018

Intract Pharma Limited is pleased to announce receipt of an award from the Bill & Melinda Gates Foundation to fund investigation of Intract’s Soteria® technology as a means to stabilise orally-administered therapeutic antibodies.

GI diseases caused by pathogens such as Enterotoxigenic Escherichia coli (ETEC) and Campylobacter are a major cause of morbidity and mortality in infants in the developing world, with ETEC alone responsible for an estimated 400 million cases of diarrhoea and 157,000 deaths/year.

Intract’s Soteria technology is a unique formulation which stabilises bio-therapeutic drugs within the GI tract, allowing the possibility for creation of oral formulations of complex biologic molecules which normally can only be administered by injection. Soteria will be utilised in the Gates Foundation-funded project to enhance the therapeutic effect of antibodies which specifically target the disease-causing bacteria without damaging the natural healthy microbiome.

Bill Lindsay, CEO of Intract said “Intract is extremely pleased to be working with the Bill & Melinda Gates Foundation on this exciting and important project. We believe that our technology and expertise in understanding the behaviour of drugs in the GI tract will maximise the chances of development of a unique, life-saving therapy”


About Intract Pharma

Intract Pharma is an oral drug delivery specialist, developing state-of-the-art formulation technologies and unique gastrointestinal models to develop advanced new therapeutics. Since its inception, Intract has pursued innovation in oral drug delivery as a means to improve on current therapies, making them safer and more effective for patients. Soteria® is available for license exclusively from Intract Pharma. For more information visit www.intractpharma.com

An independent review published by Pharmaceutical Technology has listed Intract Pharma’s Phloral® technology among top 4 approaches to oral drug delivery which offer more patient-centric drug delivery for improved patient outcomes.

The review recognizes that the radical improvement in targeting of medications to the colon achieved by Phloral® offers direct benefit to patients by ensuring that medicines consistently reach the appropriate site of action irrespective of gastrointestinal pH variation or transit times as may be exhibited in patients with gastrointestinal illness.

The review discusses three additional earlier-stage technologies from both commercial companies and academia and which are set to revolutionize drug delivery in their fields.


Click here to read the article.



  1. Siew, “Emerging Technologies Advance Oral Drug Delivery,” Pharmaceutical Technology42 (6) 18–20 (2018).

Intract Pharma will be speaking at this year’s Antibody Engineering and Therapeutics Conference in Sand Diego, CA. The event – held annually – will be hosted at the Manchester Grand Hyatt Hotel, and features both industrial and academic delegates, includes a broad range of presentations, workshops and panel sessions.


Our session: Soteria®: Revolutionizing Oral Delivery of Antibodies will be presented by Vipul Yadav, PhD, Director of Product Development at Intract Pharma. The presentation touches on the challenges of delivering biologics orally – including monoclonal antibodies – and how Intract has developed Soteria® to overcome these difficulties.


If you would like to attend this session you can book here or contact us at info@intractpharma.com for more information.



Intract Pharma’s Soteria® technology was recently profiled on Europe’s leading biotech news website, Labiotech.eu. The article comments on the potential benefit of the Soteria® technology, highlighting that oral versions of existing antibody therapies “could make the treatments easier for patients and increase compliance.” Also discussed is the £1.4m grant awarded to Intract by Innovate UK to develop a scalable manufacturing process for an oral antibody product using Soteria®.

With over 100,000 monthly visitors to the website, Labiotech.eu covers the medical, industrial and food biotech sectors over a range of different platforms.

You can find the article here:


You can also find Intract on Labiotech’s map of European Biotech companies here:



From the 4th to the 7th June 2018 members of Intract Pharma attended the BIO International Convention, participating in over 30 meetings with Pharma and Biotech leaders from around the world.

Held over four days, the convention saw over 18,000 delegates in attendance and set a new Guinness World record the Largest Business Partnering Event. If you missed us at the conference please do not hesitate to reach out to us at info@intractpharma.com

We have moved to new Office and Lab space in Camden

Intract Pharma has now taken up residence at the London Bioscience Innovation Centre (LBIC), based in Camden, London. The new lab and office, at a combined size of 1500sq ft. will allow Intract to continue to grow and flourish in our own dedicated space.

LBIC is an incubator space attached to the Royal Veterinary College and is home to over 60 biotech and life sciences companies – ranging from Multinational Pharmaceutical companies to SMEs and service providers. LBIC is located in the heart of London and is only a short walk from Kings Cross St. Pancras, Camden Town, The Crick Institute, Euston Station and of course, the UCL School of Pharmacy – where it all started.

If you would like to visit us at our new location, please contact Dan Caplin (dan.caplin@intractpharma.com) for more information.




Dr Vipul Yadav, Intract’s Director of Product development, will be presenting our Soteria technology in a talk at the European Antibody Congress. Held in Basel, and part of the wider Festival of Biologics, the congress brings together key opinion leaders in the field of biopharmaceuticals to share their research and collaborate on new ideas.

Don’t miss out on hearing about our exciting new technology and how it can revolutionise the way in which patients are treated. The presentation is part of the Technology Showcase Track and scheduled to take place at 15:35 on Tuesday 30th October (Day two of the conference).

If you would like any further details about the presentation, please contact info@intractpharma.com.

Further information on the conference can be found here: http://www.terrapinn.com/conference/european-antibody-congress/index.stm.






Intract Founder and CSO Professor Abdul Basit was recently part of a group that was awarded an Interdisciplinary Research Collaboration (IRC) grant by EPSRC worth over £10m. The collaboration, led by Cambridge University and involving UCL, Imperial, Birmingham and Glasgow Universities aims to develop an array of new technologies to improve survival rates for hard-to-treat cancers. Professor George Malliaras, who leads the IRC, said “Some cancers are difficult to remove by surgery and highly invasive, and they are also hard to treat because drugs often cannot reach them at high enough concentration”. In particular, he said, “Pancreatic tumour cells are protected by dense stromal tissue, and tumours of the central nervous system by the blood-brain barrier”. The team hopes to assess and develop a range of new technologies to deliver drugs in high enough concentrations to kill cancer cells. Cancer scientists and clinicians from the Cancer Research UK Cambridge Centre and partner sites will carry out clinical trials. The UCL team will focus on manufacturing technologies to ensure the novel devices are able to be manufactured and robust enough to withstand surgical manipulation. Prof Simon Gaisford said “Our expertise and world-leading experience in designing and manufacturing pharmaceutical products with 3D printing means we are ideally equipped to scale-up and manufacture the exciting drug delivery technologies that will be developed by our project partners”. Prof Basit added “We are very excited to be able to work on such an innovative and exciting project and we look forward to taking 3D printed medicines into the clinic to improve patient outcomes”.