Gastrointestinal Stability
and Permeability Models

Accurately Determine the Gastrointestinal Behavior of
Drugs in Humans and Animals

The gut lumen is a complex and dynamic environment presenting several barriers to oral drug delivery. The variable pH range, plethora of intestinal and bacterial enzymes, and presence of numerous transporters has a significant impact on the solubility, stability, and absorption of drug compounds. Assessing drug behavior throughout the GI tract is a critical pre-formulation step to support candidate selection, and to help design optimal drug delivery systems.

Assess drug solubility, stability, and permeability in the GI tract (stomach, small intestine, and colon)

Drug profiling using biological fluids and tissues from human subjects (in healthy and diseased states)

Profiling using biological fluids and tissues from relevant animal species

Comprehensive knowledge of human and animal GI physiology

Cutting-edge experience with biologics, including peptides and monocolonal antibodies

Read our scientific publications here

Capabilities and Expertise

Intract has developed unique models as a rapid and cost-effective means to evaluate drugs in the GI compartments of both animals and humans. Our strategic clinical collaborations provide unique access to biological fluids and tissue samples from healthy subjects, as well as patients with GI diseases.

The models have been used to evaluate numerous small molecules and biologics with distinct physicochemical and biopharmaceutical properties. Our comprehensive knowledge and capabilities can support both preclinical animal studies and advanced product development for greater clinical success.

Gastric and Small Intestinal Models

Our GI models can determine if limited solubility or intestinal degradation will impact drug bioavailability and efficacy.

We have unique access to human gastric fluids (HGF) and small intestinal fluids (HIF) from healthy and diseased subjects providing unparalleled in vivo predictions.

Colon Simulation Model

For over a decade, our CSM has provided unique insights into the colonic behavior of both drug compounds and product formulations.

Using bio-relevant inoculum, proprietary media, and a specialist anaerobic work-station, our model accurately mimics the conditions of the large intestine.

Tissue Models

We can assess drug behavior in specific regions of GI tissue from humans and animals including:

Mucosal stability

Localization by laser microscopy and quantification by ELISA

Permeation and bioavailability

Contact Us

Intract Pharma Limited,
29 – 39 Brunswick Square,
United Kingdom

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